This study focused on investigating English as a foreign language (EFL) gifted high school students’ challenges in classes when the integration of reading and writing was used. 103 grade 11 students from three gifted high schools in Mekong Delta were invited to participate in this study. The study adopted a descriptive, mixed method research design which employed the questionnaire and semi-structured interviews to collect data. The questionnaire, together with semi-structured interviews was used to collect data about EFL gifted high school students’ challenges of integration of reading and writing on their writing skills. The results of the study proved that students faced difficulties in integrating reading into writing lessons at a medium level, in relation to materials and integration tasks. However, the participants faced the greatest challenge in terms of personal backgrounds.