Listening skill plays an important role in studying a foreign language, especially English. However, students face a lot of difficulties in English listening. The research was carried out to find the problems that the sophomores encounter in English listening. The participants of this research were seventy-five English majored sophomores of English classes, course 14 at Tay Do University. Questionnaire and paper interview were delivered to collect problems. This was a quantitative and qualitative research. The results of the study showed that vocabulary, pronunciation, background knowledge and psychological factors were the major listening comprehension difficulties. Basing on these difficulties, English learners can find out suitable learning ways to improve their listening skill. The results of this study may also be useful for those who are interested in this field.